# Computational Research Scientist, Center for Cellular Therapies and Cancer Immunology Source: https://realanalystjobs.com/job/computational-research-scientist-center-for-cellular-therapies-and-cancer-immuno-091ef3dc Computational Research Scientist, Center for Cellular Therapies and Cancer Immunology at UT Southwestern Medical Center, an on-site role based in 5323 Harry Hines Blvd, Texas, USA. Experience level: 75 Years. First seen on RealAnalystJobs on 15 November 2026, read from UT Southwestern Medical Center's own careers page (Taleo), which RealAnalystJobs re-checks daily and removes the role when it closes. UT Southwestern Medical Center has approved H-1B petitions on USCIS record (employer-wide, not a promise for this role). Updated 15 November 2026. ## Key facts - Company: [UT Southwestern Medical Center](https://realanalystjobs.com/companies/ut-southwestern-medical-center) - Location: 5323 Harry Hines Blvd, Texas, USA - Work mode: On-site - First seen: Nov 15, 2026 - Employment type: Full time - Experience level: 75 Years - Source: UT Southwestern Medical Center's careers page (Taleo), re-checked daily ## Visa sponsorship The posting does not say. UT Southwestern Medical Center had H-1B petitions approved for 250 workers in fiscal year 2026 (USCIS). That is history, not a promise for this role. [See the record](https://realanalystjobs.com/companies/ut-southwestern-medical-center#h1b-record) ## About this role WHY UT SOUTHWESTERN? With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to U.S. News & World Report , we invest in you with opportunities for career growth and development to align with your future goals. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you'll discover a culture of teamwork, professionalism, and a rewarding career! JOB SUMMARY Leads the design and implementation of High-Performance Scientific Computing infrastructure. Performs and supports scientific research using technical knowledge of software, software development, complex databases, high-performance computing, and/or hardware in a complex computing environment. Performs scientific research using knowledge of formalisms and algorithms from mathematics, statistics, and/or computer science. The Center for Cellular Therapies and Cancer Immunology in the Harold C. Simmons Comprehensive Cancer Center is looking to hire a Computational Research Scientist at the interface of machine learning, cancer genomics, and immunology. You will build and apply computational methods that turn large-scale multi-omic and functional datasets into validated therapeutic hypotheses, while working side by side with experimental and translational scientists to bring those hypotheses to the clinic. This is a senior, high-autonomy position suited to someone who wants their models to drive biological discovery to therapies. You will help set scientific direction, mentor junior computational and experimental scientists, and serve as the analytical backbone of a program developing novel immunotherapies within a new center. What you will do • Build predictive models that integrate genomic, transcriptomic, epigenomic, single-cell, and functional-screen data to nominate novel therapeutic targets in cancer and the tumor immune microenvironment. • Drive immunotherapy engineering by applying machine learning to antigen and neoantigen discovery, de novo protein design, and the optimization of engineered immune cells. • Develop methods for interpreting high-dimensional and perturbation data, including deep learning approaches to sequence, structure, and single-cell readouts. • Partner closely with wet-lab scientists to design experiments, prioritize candidates for validation, and iterate rapidly between computation and the bench. • Lead and mentor trainees and staff, set analytical standards, and help shape the scientific roadmap of the program. • Communicate results through high-impact publications, presentations, and collaborations across UT Southwestern’s research and clinical community. Areas of focus Depending on your interests and strengths, your work can center on identifying novel cancer immunotherapy targets and/or developing novel therapeutics. Approaches may include: • Machine learning applied to multi-omic, single-cell, and functional data • Clinical - molecular correlations that link genotype and tumor biology to therapeutic response • De novo protein design • Computational proteomics Preferred Qualifications Education o Ph.D. in Bioinformatics, Computational Biology, Biomedical Engineering, or related field o Master’s degree in computer science, Electrical Engineering, or related field Experience o 2 years experience in driving computational biology/machine learning projects. o 4 years experience in driving computational biology/machine learning projects with Master's Degree. o Post-doctoral fellowship preferred. BENEFITS UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include: • PPO medical plan, available day one at no cost for full-time employee-only coverage • 100% coverage for preventive healthcare-no copay • Paid Time Off, available day one • Retirement Programs through the Teacher Retirement System of Texas (TRS) • Paid Parental Leave Benefit • Wellness programs • Tuition Reimbursement • Public Service Loan Forgiveness (PSLF) Qualified Employer • Learn more about these and other UTSW employee benefits! EXPERIENCE AND EDUCATION Required • Education PhD In Computer Science, Electrical Engineering, or related field or Master's Degree In Computer Science, Electrical Engineering, or related field • Experience 2 years Experience in software development/engineering and/or HPC systems management with PhD. or 4 years Experience in software development/engineering and/or HPC systems management with Master's Degree. JOB DUTIES • Designs and implements the high-performance scientific computing infrastructure for for large, multi-institution projects, including software applications, workflows, servers, databases, long-term and short-term storage solutions, and cloud services. • Serves as a domain expert for research and industry collaborations on biomedical computational methods, algorithms and platforms. Subject matter expert in multiple areas of computing technology. • Leads and develops proof-of-concepts (PoCs) for solutions applied to biomedical and clinical science use-cases by working closely with industry collaborators. • Designs, develops, implements and optimizes algorithms and scientific workflows for high dimensional data in biomedical and clinical sciences. • Develops software and methods to explore, analyze and visualize biological data sets. • Demonstrates and craft applications of cutting-edge visual computing technologies and connect them to core infrastructure. • Report research results in journal articles, conference papers, and technical manuals. • Men Description from UT Southwestern Medical Center's public careers feed, reproduced so you can read the role here. Apply on the company's own site; Real Analyst Jobs never submits anything for you. ## How to apply Open [this role on Real Analyst Jobs](https://realanalystjobs.com/job/computational-research-scientist-center-for-cellular-therapies-and-cancer-immuno-091ef3dc) and use Apply now there to reach the employer's application. The listing is re-checked against UT Southwestern Medical Center's careers page daily and removed when it closes. ## UT Southwestern Medical Center 16 open analyst roles on Real Analyst Jobs. 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